Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials

Diksha Sharma; Radha; Manoj Kumar; Adolfo Andrade-Cetto; Sunil Puri; Amit Kumar; Mamta Thakur; Deepak Chandran; Ashok Pundir; Suraj Prakash; Ravi Pandiselvam; Surinder Sandhu; Ananya Khosla; Sunil Kumar; Jose M Lorenzo

doi:10.1002/cbdv.202301086

Chemical Diversity and Medicinal Potential of Vitex negundo L.: From Traditional Knowledge to Modern Clinical Trials

Chem Biodivers. 2023 Nov;20(11):e202301086. doi: 10.1002/cbdv.202301086. Epub 2023 Nov 2.

Authors

Diksha Sharma¹, Radha¹, Manoj Kumar^{2

3}, Adolfo Andrade-Cetto⁴, Sunil Puri¹, Amit Kumar⁵, Mamta Thakur¹, Deepak Chandran⁶, Ashok Pundir⁷, Suraj Prakash¹, Ravi Pandiselvam⁸, Surinder Sandhu⁹, Ananya Khosla¹⁰, Sunil Kumar¹¹, Jose M Lorenzo¹²

Affiliations

¹ School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India.
² Chemical and Biochemical Processing Division, ICAR- Central Institute for Research on Cotton Technology, Mumbai, 400019, India.
³ Department of Biology, East Carolina University, Greenville, 27858, USA.
⁴ Laboratorio de Etnofarmacología, Departamento de BiologíaCelular, Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N, Coyoacán, C.U., Mexico City, 04510, Mexico.
⁵ GLA University, Mathura, Uttar Pradesh, 281 406, India.
⁶ Department of Animal Husbandry, Government of Kerala, Palakkad, 679335, Kerala, India.
⁷ School of Mechanical and Civil Engineering, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India.
⁸ Division of Physiology, Biochemistry and Post-Harvest Technology, ICAR - Central Plantation Crops Research Institute (CPCRI), Kasaragod, 671 124, Kerala, India.
⁹ Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, 141004, India.
¹⁰ Stanford University, 450 Serra Mall, Stanford, California, USA, 94305.
¹¹ Indian Institute of Farming Systems Research, Modipuram, 250110, India.
¹² CentroTecnológico de la Carne de Galicia, rúa Galicia n○ 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain.

PMID: 37851484
DOI: 10.1002/cbdv.202301086

Abstract

In Vedic context, Nirgundi (V. negundo) has been utilized for its anti-inflammatory, analgesic, and wound-healing properties. It has been employed to alleviate pain, treat skin conditions, and address various ailments. The plant's leaves, roots, and seeds have all found applications in traditional remedies. The knowledge of Nirgundi's medicinal benefits has been passed down through generations, and it continues to be a part of Ayurvedic and traditional medicine practices in India.

Keywords: ethnomedicinal; nirgundi; pharmacological; phytochemical; vitexin.

Publication types

Review

MeSH terms

India
Medicine, Traditional
Phytotherapy*
Plant Extracts / analysis
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plant Leaves / chemistry
Vitex* / chemistry

Substances

Plant Extracts