Assessment of renal function and prevalence of acute kidney injury following coronary artery bypass graft surgery and associated risk factors: A retrospective cohort study at a tertiary care hospital in Islamabad, Pakistan

Medicine (Baltimore). 2023 Oct 20;102(42):e35482. doi: 10.1097/MD.0000000000035482.

Abstract

Acute kidney injury (AKI) is a sudden decline in renal function after cardiac surgery. It is characterized by a significant reduction in glomerular filtration rate, alterations in serum creatinine (S.Cr) levels, and urine output. This study aimed to retrospectively analyze a cohort of 704 patients selected using stringent inclusion and exclusion criteria. AKI was defined by an increase of 0.3 mg/dL in S.Cr levels compared to baseline. Data were collected from the hospital and analyzed using SPSS 16.0. Data analysis revealed that 22% (n = 155) of the patients developed AKI on the second post-operative day, accompanied by a substantial increase in S.Cr levels (from 1.064 ± 0.2504 to 1.255 ± 0.2673, P < .000). Age and cardiopulmonary bypass duration were identified as risk factors along with ejection fraction and days of hospital stay, contributing to the development of AKI. Early renal replacement therapy can be planned when the diagnosis of AKI is established early after surgery.

MeSH terms

  • Acute Kidney Injury* / diagnosis
  • Acute Kidney Injury* / epidemiology
  • Acute Kidney Injury* / etiology
  • Cardiopulmonary Bypass / adverse effects
  • Coronary Artery Bypass* / adverse effects
  • Creatinine
  • Humans
  • Kidney / physiology
  • Pakistan / epidemiology
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Tertiary Care Centers

Substances

  • Creatinine