Leptomeningeal metastasis from solid tumours: EANO-ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

E Le Rhun; M Weller; M van den Bent; D Brandsma; J Furtner; R Rudà; D Schadendorf; J Seoane; J-C Tonn; P Wesseling; W Wick; G Minniti; S Peters; G Curigliano; M Preusser; EANO Guidelines Committee and ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

doi:10.1016/j.esmoop.2023.101624

Leptomeningeal metastasis from solid tumours: EANO-ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

ESMO Open. 2023 Oct;8(5):101624. doi: 10.1016/j.esmoop.2023.101624. Epub 2023 Sep 19.

Authors

Affiliations

¹ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland; Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
² Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
³ Department of The Brain Tumour Center at the Erasmus MC Cancer Institute, Rotterdam.
⁴ Department of Neuro-Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁵ Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria.
⁶ Division of Neuro-Oncology, Department of Neuroscience, University of Turin, Turin, Italy.
⁷ Department of Dermatology, University Hospital Essen, Essen; University of Duisburg-Essen, Essen; German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany.
⁸ Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital (HUVH), Universitat Autònoma de Barcelona, Institució Catalana de Recerca i Estudis Avançats (ICREA), CIBERONC, Barcelona, Spain.
⁹ Department of Neurosurgery, Ludwig-Maximilians-University School of Medicine, Munich; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
¹⁰ Department of Pathology, Amsterdam University Medical Centers/VUmc and Brain Tumour Center, Amsterdam; Princess Máxima Center for Paediatric Oncology, Utrecht, The Netherlands.
¹¹ Neurology Clinic, Heidelberg University Hospital, Heidelberg; Clinical Cooperation Unit Neuro-Oncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
¹² Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Policlinico Umberto I, Rome; IRCCS Neuromed, Pozzilli IS, Italy.
¹³ Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne University, Lausanne, Switzerland.
¹⁴ European Institute of Oncology, IRCCS, Milan; Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy.
¹⁵ Division of Oncology, Department of Medicine 1, Medical University, Vienna, Austria.

Abstract

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This Clinical Practice Guideline provides recommendations for managing leptomeningeal metastases from solid tumours.
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The guideline covers clinical, imaging and cytological diagnosis, staging and risk assessment, treatment and follow-up.
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A treatment and management algorithm is provided.
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The author panel encompasses a multidisciplinary group of experts from different institutions and countries in Europe.
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Recommendations are based on available scientific data and the authors’ collective expert opinion.

Keywords: central nervous system; cerebral; cerebrospinal fluid; clinical practice guideline; neurological; recommendations.

Publication types

Practice Guideline
Research Support, Non-U.S. Gov't

MeSH terms

Follow-Up Studies
Humans
Neoplasms* / therapy