Rapid enzymatic activity model (REAM) to decipher the toxic action of per- and polyfluoroalkyl substances

Precious Obiako; Amanda Sevcik; Christie M Sayes

doi:10.1016/j.fct.2023.114117

Rapid enzymatic activity model (REAM) to decipher the toxic action of per- and polyfluoroalkyl substances

Food Chem Toxicol. 2023 Dec:182:114117. doi: 10.1016/j.fct.2023.114117. Epub 2023 Oct 28.

Authors

Precious Obiako¹, Amanda Sevcik¹, Christie M Sayes²

Affiliations

¹ Department of Environmental Science, Baylor University, Waco, TX, 76798, USA.
² Department of Environmental Science, Baylor University, Waco, TX, 76798, USA. Electronic address: [email protected].

PMID: 37898236
DOI: 10.1016/j.fct.2023.114117

Abstract

Per- and polyfluoroalkyl substances (PFAS) have been identified as emerging contaminants and human exposure to these substances is a rising public health concern. We have developed a rapid enzymatic activity model (REAM), which can serve as a cell-free screening tool that elucidates possible mechanisms of toxic action inexpensively and quickly for these and other environmentally relevant chemicals.

Keywords: Antioxidant defense; Catalase; Cellular metabolism; Glutathione reductase; Lactate dehydrogenase; Pyruvate dehydrogenase.

MeSH terms

Alkanesulfonic Acids*
Fluorocarbons* / toxicity
Humans
Public Health

Substances

Fluorocarbons
Alkanesulfonic Acids