Estrogen modifies the circadian timing and amplitude of the luteinizing hormone surge in female hamsters exposed to short photoperiods

Biol Reprod. 1986 Oct;35(3):516-23. doi: 10.1095/biolreprod35.3.516.

Abstract

LH surges occur 3 h later in intact anovulatory hamsters exposed to nonstimulatory photoperiods (6L:18D) for 8 wk than the proestrous LH surges from the same hamsters housed in 6L:18D for 3 weeks. In ovariectomized hamsters housed in 6L:18D for 3 wk, the LH surge was observed at the same time of day as in intact anovulatory hamsters at 8 wk. Implanting Silastic capsules containing estradiol benzoate (EB) advanced the timing of the daily surge of LH in ovariectomized hamsters housed in 6L:18D for 8 wk. EB also affected the magnitude of the LH surge in hamsters housed in 6L:18D for 8 wk. Two days after receiving EB implants, daily LH surges in anovulatory hamsters were suppressed by 75% and in ovariectomized "regressed" hamsters by 37%. This difference between groups was probably due to ovarian progesterone in intact animals. Estrogen is not required for LH surges in anovulatory hamsters but suppresses LH release when administered exogenously. The delay in the timing of the LH surge in anovulatory hamsters may result from the decline in estrogen resulting from short photoperiod exposure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Circadian Rhythm / drug effects*
  • Cricetinae
  • Delayed-Action Preparations
  • Estradiol / pharmacology
  • Estrogens / pharmacology*
  • Estrus
  • Female
  • Light*
  • Luteinizing Hormone / blood*
  • Mesocricetus
  • Ovariectomy

Substances

  • Delayed-Action Preparations
  • Estrogens
  • Estradiol
  • Luteinizing Hormone