Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies - case report and brief review

Clin Immunol Commun. 2023 Dec 15:4:55-59. doi: 10.1016/j.clicom.2023.08.001. Epub 2023 Sep 1.

Abstract

We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of patient sera. A brief review of immunodeficiency caused by anti-IFNγ autoantibodies is also described.

Keywords: Anti-interferon gamma autoantibodies; Haemophagocytic lymphohistiocytosis; Tuberculosis.