Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation

Affiliations

• ¹ Department of Microbiology, Immunology and Transplantation, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium.
• ² Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
• ³ Necker Medical School, Paris Descartes University, Paris, France.
• ⁴ Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.
• ⁵ Imagine Institute, Paris Descartes University Paris, France.
• ⁶ Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, AP-HP Paris, France.
• ⁷ Department of Pharmaceutical and Pharmacological Sciences, Therapeutic and Diagnostic Antibodies, KU Leuven, Leuven, Belgium.
• ⁸ Department of Pediatrics, Jessa Hospital, Hasselt, Belgium.
• ⁹ Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
• ¹⁰ Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.
• ¹¹ Department of Pediatrics, Antwerp Hospital Network, Antwerp, Belgium.
• ¹² Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children Paris, France.
• ¹³ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• ¹⁴ Howard Hughes Medical Institute, New York, NY, USA.
• ¹⁵ Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
• ¹⁶ Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.