Leveraging human immune organoids for rational vaccine design

Jenna M Kastenschmidt; Suhas Sureshchandra; Lisa E Wagar

doi:10.1016/j.it.2023.10.008

Leveraging human immune organoids for rational vaccine design

Trends Immunol. 2023 Dec;44(12):938-944. doi: 10.1016/j.it.2023.10.008. Epub 2023 Nov 6.

Authors

Jenna M Kastenschmidt¹, Suhas Sureshchandra¹, Lisa E Wagar²

Affiliations

¹ Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92617, USA; Institute for Immunology, University of California Irvine, Irvine, CA, 92617, USA; Center for Virus Research, University of California Irvine, Irvine, CA, 92617, USA; Vaccine R&D Center, University of California Irvine, Irvine, CA, 92617, USA.
² Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92617, USA; Institute for Immunology, University of California Irvine, Irvine, CA, 92617, USA; Center for Virus Research, University of California Irvine, Irvine, CA, 92617, USA; Vaccine R&D Center, University of California Irvine, Irvine, CA, 92617, USA. Electronic address: [email protected].

PMID: 37940395
DOI: 10.1016/j.it.2023.10.008

Abstract

Current influenza A and B virus (IABV) vaccines provide suboptimal protection and efforts are underway to develop a universal IABV vaccine. Blood neutralizing antibodies are the current gold standard for protection, but many processes that regulate human IABV-specific immunity occur in mucosal and lymphoid tissues. We need an improved mechanistic understanding of how immune cells respond within these tissues to advance our current (slow and expensive) vaccine testing model. We posit that advanced in vitro models of human adaptive immunity can bridge some of the gaps between vaccine design, animal models, and human clinical trials. Here, we highlight how they can be integrated into current practices and play a role in reverse translating the defined features of protective vaccines to rationally design new candidates.

Keywords: human immunity; immune organoids; influenza; rational vaccine design; systems immunology; vaccines.

Publication types

Review

MeSH terms

Adaptive Immunity
Animals
Antibodies, Neutralizing
Antibodies, Viral
Humans
Influenza Vaccines*
Influenza, Human* / prevention & control
Organoids

Substances

Antibodies, Viral
Influenza Vaccines
Antibodies, Neutralizing