Indirect impact of PCV10 children vaccination on the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae causing invasive disease in adults over 50 in Colombia, 2005-2019: Observational analysis

Carolina Duarte; Clara Inés Agudelo; Carlos Castañeda-Orjuela; Jaime Moreno; Olga Marina Sanabria; Adriana Bautista; Elizabeth Castañeda

doi:10.1016/j.eimce.2023.07.008

Indirect impact of PCV10 children vaccination on the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae causing invasive disease in adults over 50 in Colombia, 2005-2019: Observational analysis

Enferm Infecc Microbiol Clin (Engl Ed). 2023 Nov 7:S2529-993X(23)00259-9. doi: 10.1016/j.eimce.2023.07.008. Online ahead of print.

Authors

Carolina Duarte¹, Clara Inés Agudelo², Carlos Castañeda-Orjuela³, Jaime Moreno², Olga Marina Sanabria², Adriana Bautista², Elizabeth Castañeda²

Affiliations

¹ Grupo de Microbiología, Instituto Nacional de Salud (INS), Bogotá, Colombia. Electronic address: [email protected].
² Grupo de Microbiología, Instituto Nacional de Salud (INS), Bogotá, Colombia.
³ Observatorio Nacional de Salud, Instituto Nacional de Salud (INS), Bogotá, Colombia.

PMID: 37945464
DOI: 10.1016/j.eimce.2023.07.008

Abstract

Introduction: The introduction of pneumococcal conjugate vaccine (PCV) into childhood vaccination programmes has reduced the prevalence of vaccine serotypes (VTs) that cause invasive pneumococcal disease (IPD) in children. In the elderly population, an impact has also been seen through indirect protection (herd effect). The aim of this study was to estimate the changes in serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae isolates recovered from adult IPD and to evaluate the indirect effect of immunization with PCV10 based on laboratory records by analyzing the period from 2005 to 2019 for six years before and eight years after the universal PCV10 administration to Colombian children.

Methods: A total of 2204 S. pneumoniae isolates from adults (≥50 years) with IPD were analyzed. The analysis examined the percentage changes in proportions (prevalence) and percentage variations in population rates (annual reported rates - ARR) of VTs between the pre-PCV10 (2005-2009) and post-PCV10 (2015-2019) periods.

Results: The findings were (1) evidence of a significant percentage decrease of pneumococcal VT10 causing IPD in adults (50% pre-PCV10 and 16% post-PCV10); (2) significant increase of serotype 19A (from 1.6% to 14.8%) and less important increase of serotype 3 (from 10.5% to 14.5%) and non-vaccine serotypes (NVT) (from 21.4% to 38.4%) non-significant; and (3) meningitis and non-meningitis multidrug resistant isolates associated with serotype 19A. An improvement in the surveillance system is associated with the immunization of children, as noted by the increased ARRs across the analysis period.

Conclusions: Our results show the indirect impact of PCV10 vaccination in children on the VT10 distribution and antimicrobial resistance of S. pneumoniae causing IPD in Colombian adults over 50 when comparing the pre-PCV10 (2005-2009) and post-PCV10 (2015-2019) periods.

Keywords: Adultos; Adults; Colombia; Pneumococcal vaccines; Serotypes; Streptococcus pneumoniae; Vaccination; Vacunación; Vacunas antineumocócicas, Serotipos.