Mouse TMC4 is involved in the detection of chloride taste of salts

Masataka Narukawa; Aya Masago; Momo Murata; Yoshikazu Saito; Yoichi Kasahara; Keiko Abe; Tomiko Asakura

doi:10.1093/bbb/zbad155

Mouse TMC4 is involved in the detection of chloride taste of salts

Biosci Biotechnol Biochem. 2024 Jan 24;88(2):203-205. doi: 10.1093/bbb/zbad155.

Authors

Masataka Narukawa¹, Aya Masago¹, Momo Murata¹, Yoshikazu Saito^{2

3}, Yoichi Kasahara², Keiko Abe², Tomiko Asakura^{2

4}

Affiliations

¹ Department of Food and Nutrition, Kyoto Women's University , Kyoto City, Kyoto, Japan.
² Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo City, Tokyo, Japan.
³ Research Department, Toyo Institute of Food Technology , Kawanishi City, Hyogo, Japan.
⁴ Department of Liberal Arts, The Open University of Japan , Chiba City, Chiba, Japan.

PMID: 37947260
DOI: 10.1093/bbb/zbad155

Abstract

Licking behavior with various salts in transmembrane channel-like 4 (Tmc4) knockout (KO) mice was observed. In Tmc4 KO mice, a significant decrease in sensitivity to chloride salts, such as NaCl, KCl, and NH4Cl, was observed, while no significant decrease in sensitivity to Na-gluconate was observed. This finding suggests that TMC4 may be involved in the detection of chloride taste.

Keywords: TMC4; chloride channel; chloride salt; licking behavior; salty taste.

MeSH terms

Amiloride
Animals
Chlorides*
Mice
Mice, Knockout
Potassium Chloride / pharmacology
Salts*
Taste

Substances

Amiloride
Chlorides
Potassium Chloride
Salts

Abstract

MeSH terms

Substances

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