The use of nifedipine for the treatment of achalasia in children

J Pediatr Gastroenterol Nutr. 1986 Nov-Dec;5(6):883-6. doi: 10.1097/00005176-198611000-00010.

Abstract

Four adolescents with achalasia were treated with nifedipine. All the patients' symptoms improved dramatically. On manometric evaluation, following oral nifedipine, the lower esophageal sphincter pressure decreased approximately 50%. No change in esophageal peristaltic activity was noted. Side effects were minimal; two patients had mild headache initially. Nifedipine, which is commonly used in adult patients with achalasia, may be beneficial for short-term symptomatic relief in children until more definitive therapy can be performed.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Deglutition Disorders / etiology
  • Esophageal Achalasia / complications
  • Esophageal Achalasia / drug therapy*
  • Esophageal Achalasia / physiopathology
  • Esophagus / physiopathology
  • Female
  • Humans
  • Male
  • Manometry
  • Nifedipine / therapeutic use*

Substances

  • Nifedipine