Case report: Paroxysmal nocturnal hemoglobinuria presenting with hemorrhagic esophageal varices

Runsen Du; Lihua Zheng; Peng Liu; Yaheng Zhao; Yan Yang; Lei Zhang; Zengren Zhao

doi:10.3389/fmed.2023.1276030

Case report: Paroxysmal nocturnal hemoglobinuria presenting with hemorrhagic esophageal varices

Front Med (Lausanne). 2023 Oct 25:10:1276030. doi: 10.3389/fmed.2023.1276030. eCollection 2023.

Authors

Runsen Du^{1

2}, Lihua Zheng², Peng Liu², Yaheng Zhao², Yan Yang², Lei Zhang², Zengren Zhao¹

Affiliations

¹ Department of Gastrointestinal Surgery, The First Hospital of Hebei Medical University, Hebei, China.
² Department of Vascular Surgery, The First Hospital of Hebei Medical University, Hebei, China.

Abstract

We report the case of a female who was cured of hemorrhagic esophageal varices caused by paroxysmal nocturnal hemoglobinuria (PNH) through transjugular intrahepatic portosystemic shunt (TIPS) treatment. PNH complicated by portal vein and visceral veins thrombosis without hepatic veins is extremely rare, and as such, it is easy to incorrectly treat due to lack of awareness. Hemorrhagic esophageal varices due to PNH with PVT have been reported in one case in 1974, and here, we report the second.

Keywords: TIPS; esophageal varices; hemorrhagic esophageal varices; paroxysmal nocturnal hemoglobinuria; portal vein thrombosis.

Publication types

Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.