The oral cavity is the ultimate doorway for microbes entering the human body. We analyzed oral microbiota dynamics in allogeneic hematopoietic stem-cell transplant recipients and showed that microbiota injury and recovery patterns were highly informative on transplant complications and outcomes. Our results highlight the importance of tracking the recipient's microbiota changes during allogeneic hematopoietic stem-cell transplant to improve our understanding of its biology, safety, and efficacy.
Keywords: 16S rRNA gene sequencing; allogeneic hematopoietic cell transplant; biomarkers; blooming of bacteria; clinical outcomes; microbiome stability; oral microbiome.