NUT Expression Is of Diagnostic Utility in the Distinction of Digital Papillary Carcinoma From Poroid Hidradenoma

Jean Iacobelli; Nathan T Harvey; Nima Mesbah Ardakani; Lydia Ng; Henry Preston; Benjamin A Wood

doi:10.1097/DAD.0000000000002596

NUT Expression Is of Diagnostic Utility in the Distinction of Digital Papillary Carcinoma From Poroid Hidradenoma

Am J Dermatopathol. 2024 Feb 1;46(2):98-100. doi: 10.1097/DAD.0000000000002596. Epub 2023 Nov 14.

Authors

Jean Iacobelli^{1

2}, Nathan T Harvey^{1

2}, Nima Mesbah Ardakani^{1

2}, Lydia Ng^{1

2}, Henry Preston³, Benjamin A Wood^{1

2}

Affiliations

¹ Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.
² The University of Western Australia, Perth, Australia; and.
³ Fremantle Pathology Level 1, Fremantle, Australia.

PMID: 37982500
DOI: 10.1097/DAD.0000000000002596

Abstract

The distinction between digital papillary adenocarcinoma (DPAC) and benign cutaneous adnexal tumors is clinically important and can be challenging. Poroid hidradenoma frequently occurs at acral sites and can show a number of histological features, which overlap with digital papillary adenocarcinoma. Recent work has shown that YAP1-NUTM1 fusions are frequent in poroid hidradenoma and are associated with nuclear protein in testis (NUT) expression by immunohistochemistry. We evaluated the expression of NUT-1 by immunohistochemistry in 4 cases of DPAC and 4 cases of poroid hidradenoma. Three of 4 cases of poroid hidradenoma showed strong NUT-1 expression, with no staining in any of the cases of DPAC. These results suggest that NUT-1 immunohistochemistry may be a useful additional tool in evaluating this differential diagnosis.

MeSH terms

Acrospiroma* / pathology
Adenocarcinoma, Papillary*
Carcinoma, Papillary*
Humans
Male
Poroma*
Sweat Gland Neoplasms* / diagnosis
Sweat Gland Neoplasms* / genetics
Sweat Gland Neoplasms* / metabolism

Supplementary concepts

Poroid hidradenoma