Acquired factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases

Arab J Gastroenterol. 2023 Nov;24(4):256-258. doi: 10.1016/j.ajg.2023.10.002. Epub 2023 Nov 22.

Abstract

Bleeding disorders can exacerbate gastrointestinal bleeding in inflammatory bowel disease (IBD) at the time of diagnosis or flares. Factor VII (FVII) deficiency is a life-threatening rare congenital bleeding disorder in childhood. This study describes three adolescent patients with IBD accompanied by acquired FVII deficiency. This is the first case series of patients with IBD accompanied by FVII deficiency. We hypothesized that inflammation, accelerated consumption, disease severity, and weight loss can cause decreased FVII activity in patients diagnosed with IBD. To control intestinal bleeding, we must keep in mind factor deficiencies in IBD.

Keywords: Children; Factor VII deficiency; Inflammatory bowel disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Factor VII Deficiency* / complications
  • Factor VII Deficiency* / congenital
  • Factor VII Deficiency* / diagnosis
  • Factor VIIa
  • Gastrointestinal Hemorrhage / etiology
  • Humans
  • Inflammatory Bowel Diseases* / complications
  • Patient Acuity

Substances

  • Factor VIIa