Histologic characterization of primary ciliary dyskinesia chronic rhinosinusitis

Int Forum Allergy Rhinol. 2024 May;14(5):990-994. doi: 10.1002/alr.23303. Epub 2023 Nov 23.

Abstract

We present the largest cohort of structured histopathology reports on primary ciliary dyskinesia-related chronic rhinosinusitis (PCD-CRS). Despite endoscopic differences, PCD-CRS and cystic fibrosis-related chronic rhinosinusitis (CF-CRS) had similar structured histopathology reports. Compared to healthy patients and those with idiopathic chronic rhinosinusitis without nasal polyps, patients with PCD-CRS had an increased neutrophil count.

Keywords: chronic rhinosinusitis; ciliary motility; hereditary; musocilliary clearance.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Chronic Disease
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / pathology
  • Female
  • Humans
  • Kartagener Syndrome / pathology
  • Male
  • Middle Aged
  • Nasal Polyps / pathology
  • Neutrophils / immunology
  • Neutrophils / pathology
  • Rhinosinusitis* / pathology
  • Young Adult