The synthesis of novel pyrazolothienopyridinone derivatives as potential GABAA receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds.
Supplementary information: The online version contains supplementary material available at 10.1007/s00706-023-03063-6.
Keywords: Drug research; Electron-rich heterocyclic amines; GABAA Receptor Modulators; Heterocycles; Scaffold Hopping.
© The Author(s) 2023.