The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity

Diabetes Metab Syndr Obes. 2023 Nov 20:16:3691-3705. doi: 10.2147/DMSO.S432344. eCollection 2023.

Abstract

Presently, obesity has emerged as a significant global public health concern due to its escalating prevalence and incidence rates. The gut microbiota, being a crucial environmental factor, has emerged as a key player in the etiology of obesity. Nevertheless, the intricate and specific interactions between obesity and gut microbiota, along with the underlying mechanisms, remain incompletely understood. This review comprehensively summarizes the gut microbiota characteristics in obesity, the mechanisms by which it induces obesity, and explores targeted therapies centered on gut microbiota restoration.

Keywords: dysbiosis; gut microbiota; metabolism; obesity.

Publication types

  • Review

Grants and funding

This work was supported by the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (BJ2020032), Project of Wuxi Translational Medicine Center (2020ZHYB10), Project of Wuxi Science and Technology Development Fund (Y20212004), Wuxi Taihu Lake Talent Plan, Team in Medical and Health Profession (2021), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX23_0690).