Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview

Clin Med Insights Oncol. 2023 Nov 27:17:11795549231211521. doi: 10.1177/11795549231211521. eCollection 2023.

Abstract

Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data. The influence of melatonin, light, night shift work, chronotherapy, and androgen independence are discussed as they relate to the existing literature on their role in prostate cancer.

Keywords: Prostate cancer; circadian rhythm; clock dysregulation; oncogenesis; shift work.

Publication types

  • Review