Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis

E Kojro; I Willhardt; A Römbach; Z Grzonka; P Hermann

doi:10.1016/0014-5793(87)81561-2

Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis

FEBS Lett. 1987 Feb 9;212(1):83-6. doi: 10.1016/0014-5793(87)81561-2.

Authors

E Kojro, I Willhardt, A Römbach, Z Grzonka, P Hermann

PMID: 3803610
DOI: 10.1016/0014-5793(87)81561-2

Abstract

The action of substrate analogs containing the tetrazolyl group instead of the C-terminal carboxy group on the peptidase activity of carboxypeptidase A is studied. The analogs compete with the substrate for the secondary binding site thus showing activation phenomena.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / pharmacology*
Binding Sites
Carboxypeptidases / metabolism*
Carboxypeptidases A
Catalysis
Enzyme Activation
Kinetics
Tetrazoles / pharmacology

Substances

Amino Acids
Tetrazoles
Carboxypeptidases
Carboxypeptidases A