Enhanced heterogeneous interface to construct intelligent conductive hydrogel gas sensor for individualized treatment of infected wounds

Linguo Wan; Nanjian Xu; Xiaodong Wu; Mujie Liu; Yong Liu; Jinglong Zhao; Ting Zhang; Jingwei Zhao; Yu Zhou; Qingqing Xie; Yiwei Hu; Xiaoqing Jiang; Chen Tang; Yuping Quan; Shareen Shafique; Ye Tian; Xin Zhang; Yuejun Zhang; Kun Zhou; Jiangbei Cao; Jiawen Jian; Yuheng Wang

doi:10.1016/j.ijbiomac.2023.128520

Enhanced heterogeneous interface to construct intelligent conductive hydrogel gas sensor for individualized treatment of infected wounds

Int J Biol Macromol. 2024 Feb;258(Pt 1):128520. doi: 10.1016/j.ijbiomac.2023.128520. Epub 2023 Nov 29.

Authors

Linguo Wan¹, Nanjian Xu², Xiaodong Wu³, Mujie Liu⁴, Yong Liu¹, Jinglong Zhao⁵, Ting Zhang⁵, Jingwei Zhao⁵, Yu Zhou¹, Qingqing Xie¹, Yiwei Hu⁴, Xiaoqing Jiang¹, Chen Tang¹, Yuping Quan⁶, Shareen Shafique⁷, Ye Tian¹, Xin Zhang¹, Yuejun Zhang¹, Kun Zhou⁸, Jiangbei Cao⁹, Jiawen Jian¹⁰, Yuheng Wang¹¹

Affiliations

¹ Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, Zhejiang 315211, China.
² Department of Spine Surgery, Ningbo Sixth Hospital, Ningbo, Zhejiang 315040, China. Electronic address: [email protected].
³ Department of Anesthesiology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
⁴ Medical College, Ningbo University, Ningbo, Zhejiang 315000, China.
⁵ Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang 315201, China.
⁶ Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
⁷ Department of Microelectronic Science and Engineering, Ningbo Collaborative Innovation Center of Nonlinear Calamity System of Ocean and Atmosphere, Ningbo University, Ningbo 315211, China.
⁸ School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
⁹ Department of Anesthesiology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China. Electronic address: [email protected].
¹⁰ Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: [email protected].
¹¹ Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: [email protected].

PMID: 38040150
DOI: 10.1016/j.ijbiomac.2023.128520

Abstract

In this study, we developed an enhanced heterogeneous interface intelligent conductive hydrogel NH₃ sensor for individualized treatment of infected wounds. The sensor achieved monitoring, self-diagnosis, and adaptive gear adjustment functions. The PPY@PDA/PANI(3/6) sensor had a minimum NH₃ detection concentration of 50 ppb and a response value of 2.94 %. It also had a theoretical detection limit of 49 ppt for infected wound gas. The sensor exhibited a fast response time of 23.2 s and a recovery time of 42.9 s. Tobramycin (TOB) was encapsulated in a self-healing QCS/OD hydrogel formed by quaternized chitosan (QCS) and oxidized dextran (OD), followed by the addition of polydopamine-coated polypyrrole nanowires (PPY@PDA) and polyaniline (PANI) to prepare electrically conductive drug-loaded PPY@PDA/PANI hydrogels. The drug-loaded PPY@PDA/PANI hydrogel was combined with a PANI/PVDF membrane to form an enhanced heterogeneous interfacial PPY@PDA/PANI/PVDF-based sensor, which could adaptively learn the individual wound ammonia response and adjust the speed of drug release from the PPY@PDA/PANI hydrogel with electrical stimulation. Drug release and animal studies demonstrated the efficacy of the PPY@PDA/PANI hydrogel in inhibiting infection and accelerating wound healing. In conclusion, the gas-sensitive conductive hydrogel sensing system is expected to enable intelligent drug delivery and provide personalized treatment for complex wound management.

Keywords: Ammonia sensor; Enhanced heterogeneous interface; Gas-responsive conductive hydrogel.

MeSH terms

Animals
Chitosan*
Fluorocarbon Polymers*
Hydrogels / pharmacology
Polymers*
Polyvinyls*
Pyrroles

Substances

Polymers
Hydrogels
polyvinylidene fluoride
Pyrroles
Chitosan
Fluorocarbon Polymers
Polyvinyls