Digital Twinning of Cardiac Electrophysiology Models From the Surface ECG: A Geodesic Backpropagation Approach

IEEE Trans Biomed Eng. 2024 Apr;71(4):1281-1288. doi: 10.1109/TBME.2023.3331876. Epub 2024 Mar 20.

Abstract

The eikonal equation has become an indispensable tool for modeling cardiac electrical activation accurately and efficiently. In principle, by matching clinically recorded and eikonal-based electrocardiograms (ECGs), it is possible to build patient-specific models of cardiac electrophysiology in a purely non-invasive manner. Nonetheless, the fitting procedure remains a challenging task. The present study introduces a novel method, Geodesic-BP, to solve the inverse eikonal problem. Geodesic-BP is well-suited for GPU-accelerated machine learning frameworks, allowing us to optimize the parameters of the eikonal equation to reproduce a given ECG. We show that Geodesic-BP can reconstruct a simulated cardiac activation with high accuracy in a synthetic test case, even in the presence of modeling inaccuracies. Furthermore, we apply our algorithm to a publicly available dataset of a biventricular rabbit model, with promising results. Given the future shift towards personalized medicine, Geodesic-BP has the potential to help in future functionalizations of cardiac models meeting clinical time constraints while maintaining the physiological accuracy of state-of-the-art cardiac models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Cardiac Electrophysiology
  • Electrocardiography / methods
  • Electrophysiologic Techniques, Cardiac*
  • Heart* / diagnostic imaging
  • Heart* / physiology
  • Humans
  • Rabbits