Enhancer of Zeste Homolog 2 Inhibition Induces HLA Class I Re-Expression in Merkel Cell Carcinoma

J Invest Dermatol. 2024 Jun;144(6):1398-1401.e1. doi: 10.1016/j.jid.2023.10.036. Epub 2023 Dec 3.
No abstract available

Keywords: EZH2; HLA; Immunohistochemistry; Merkel cell carcinoma; Polyomavirus.

Publication types

  • Letter

MeSH terms

  • Carcinoma, Merkel Cell* / genetics
  • Carcinoma, Merkel Cell* / immunology
  • Carcinoma, Merkel Cell* / metabolism
  • Carcinoma, Merkel Cell* / pathology
  • Cell Line, Tumor
  • Enhancer of Zeste Homolog 2 Protein* / antagonists & inhibitors
  • Enhancer of Zeste Homolog 2 Protein* / genetics
  • Enhancer of Zeste Homolog 2 Protein* / metabolism
  • Gene Expression Regulation, Neoplastic
  • Histocompatibility Antigens Class I* / genetics
  • Histocompatibility Antigens Class I* / metabolism
  • Humans
  • Skin Neoplasms* / genetics
  • Skin Neoplasms* / immunology
  • Skin Neoplasms* / metabolism
  • Skin Neoplasms* / pathology

Substances

  • Enhancer of Zeste Homolog 2 Protein
  • Histocompatibility Antigens Class I
  • EZH2 protein, human