Checkmate: Metabolic flexibility with a STING in its tail

Roddy S O'Connor

doi:10.1126/sciadv.adm6816

Checkmate: Metabolic flexibility with a STING in its tail

Sci Adv. 2023 Dec 8;9(49):eadm6816. doi: 10.1126/sciadv.adm6816. Epub 2023 Dec 6.

Author

Roddy S O'Connor^{1

2}

Affiliations

¹ Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Inhibiting a key metabolic enzyme, ACLY, in cancer cells impacts T cell function in immunotherapy-resistant tumors and may offer a target for therapeutic treatment.

Publication types

Review

MeSH terms

Humans
Neoplasms* / pathology

Grants and funding

R01 CA278837/CA/NCI NIH HHS/United States