Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception

Mov Disord. 2024 Feb;39(2):447-449. doi: 10.1002/mds.29666. Epub 2023 Dec 9.

Abstract

Dopamine exerts antinociceptive effects on pain in PD at cortical and spinal levels, whereas only cortical effects have been described for DBS, so far. By assessing the nociceptive flexion reflex (NFR) threshold at medication on, and DBS ON and OFF in two patients, we showed that DBS additionally decreases spinal nociception.

Publication types

  • Letter

MeSH terms

  • Deep Brain Stimulation*
  • Humans
  • Nociception / physiology
  • Pain / etiology
  • Pain Measurement
  • Pain Threshold / physiology
  • Parkinson Disease* / complications
  • Parkinson Disease* / therapy