Genomic and biological characteristics of a novel lytic phage, vB_MscM-PMS3, infecting the opportunistic zoonotic pathogen Mammaliicoccus sciuri

Arch Virol. 2023 Dec 11;169(1):4. doi: 10.1007/s00705-023-05940-1.

Abstract

Mammaliicoccus sciuri is an opportunistic zoonotic pathogen in humans and animals. We isolated the Mammaliicoccus phage vB_MscM-PMS3, which was also able to infect and lyse M. sciuri and M. lentus. The phage genome is a linear dsDNA that is 147,811 bp in length and contains 206 ORFs and three tRNA genes. It showed low genome coverage (< 17%) and sequence identity (< 91.3%) to other phage genomes. Phylogenetic analysis based on the whole genome and major capsid protein revealed that this phage clustered with members of the subfamily Twortvirinae of the family Herelleviridae, but it was distinctly separated from the other members, indicating its uniqueness.

MeSH terms

  • Animals
  • Bacteriophages* / genetics
  • Genome, Viral
  • Genomics
  • Humans
  • Phylogeny
  • Staphylococcus
  • Whole Genome Sequencing

Supplementary concepts

  • Staphylococcus sciuri