Genetic and Immunological Pathogenesis of Atopic Dermatitis

J Invest Dermatol. 2024 May;144(5):954-968. doi: 10.1016/j.jid.2023.10.019. Epub 2023 Dec 11.

Abstract

Type 2 immune-mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive nature of genetic and environmental contributions to atopy. From sequence variants in the epithelial barrier gene encoding FLG to the hygiene hypothesis, AD combines a broad array of contributions into a single syndrome. This review will focus on the genetic contribution to AD and where genetics facilitates the elicitation or enhancement of AD pathogenesis.

Keywords: Atopic dermatitis; Epidermal barrier; Epithelial barrier; GWAS; Genetics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Dermatitis, Atopic* / etiology
  • Dermatitis, Atopic* / genetics
  • Dermatitis, Atopic* / immunology
  • Filaggrin Proteins*
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Humans
  • Intermediate Filament Proteins / genetics

Substances

  • Filaggrin Proteins
  • FLG protein, human
  • Intermediate Filament Proteins