Polymorphisms of the NCF4 Gene Increase the Risk of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus

Yu E Azarova; E Yu Klyosova; V E Ivakin; M I Churilin; I I Kolomoets; O A Sunyaykina; V A Ragulina; A V Polonikov

doi:10.1007/s10517-023-05974-0

Polymorphisms of the NCF4 Gene Increase the Risk of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus

Bull Exp Biol Med. 2023 Nov;176(1):77-81. doi: 10.1007/s10517-023-05974-0. Epub 2023 Dec 12.

Authors

Yu E Azarova¹, E Yu Klyosova², V E Ivakin², M I Churilin², I I Kolomoets², O A Sunyaykina², V A Ragulina², A V Polonikov²

Affiliations

¹ Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. [email protected].
² Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.

PMID: 38085396
DOI: 10.1007/s10517-023-05974-0

Abstract

We showed for the first time that polymorphisms rs2075938 and rs2075938 of the NCF4 gene are associated with the risk of chronic heart failure in patients with type 2 diabetes mellitus (n=1310). In particular, haplotypes ATGTCTAT (OR=1.74, 95%CI=1.23-2.47; p=0.0017) and ATATTCAC (OR=2.83, 95%CI=1.33-6.03; p=0.0072) of NCF4 increase the risk of chronic heart failure in type 2 diabetes mellitus patients. The results show that NADPH oxidase subunit NCF4 is involved in the molecular mechanisms of myocardial damage in type 2 diabetes mellitus.

Keywords: NCF4; chronic heart failure; genetic predisposition; single nucleotide polymorphism; type 2 diabetes mellitus.

MeSH terms

Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / genetics
Genetic Predisposition to Disease / genetics
Haplotypes / genetics
Heart Failure* / genetics
Humans
NADPH Oxidases / genetics
Polymorphism, Single Nucleotide / genetics

Substances

NADPH Oxidases
NCF4 protein, human