Pediatric Extracorporeal Membrane Oxygenation Anticoagulation and Monitoring: Where We Were and Where Are We Now?

Amy L Kiskaddon; Anthony A Sochet; Arabela Stock; Vera Ignjatovic; Neil A Goldenberg

doi:10.5863/1551-6776-28.8.687

Pediatric Extracorporeal Membrane Oxygenation Anticoagulation and Monitoring: Where We Were and Where Are We Now?

J Pediatr Pharmacol Ther. 2023;28(8):687-692. doi: 10.5863/1551-6776-28.8.687. Epub 2023 Dec 12.

Authors

Amy L Kiskaddon^{1

2}, Anthony A Sochet^{3

4}, Arabela Stock^{5

6}, Vera Ignjatovic⁷, Neil A Goldenberg^{7

8

9}

Affiliations

¹ Department of Pharmacy (ALK), Johns Hopkins All Children's Hospital, St. Petersburg, FL.
² Division of Cardiology (ALK), Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
³ Department of Anesthesiology and Critical Care Medicine (AAS), Johns Hopkins University School of Medicine, Baltimore, MD.
⁴ Division of Pediatric Critical Care (AAS), Johns Hopkins All Children's Hospital, St. Petersburg, FL.
⁵ Division of Cardiac Critical Care (AS), Heart Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL.
⁶ (AS), Johns Hopkins All Children's Hospital, St. Petersburg, FL.
⁷ Institute for Clinical and Translational Research (VI, NAG), Johns Hopkins All Children's Hospital, St. Petersburg, FL.
⁸ Division of Hematology (NAG), Departments of Medicine and Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.
⁹ Cancer and Blood Disorders Institute (NAG), Johns Hopkins All Children's Hospital, St. Petersburg, FL.

Abstract

Extracorporeal membrane oxygenation (ECMO) support in neonates and pediatric patients has continued to advance. In addition to technologic progress, there is a growing interest in the anticoagulation agents and laboratory monitoring strategies used in children requiring ECMO support. This review summarizes current available evidence and provides guidance for clinicians regarding anticoagulation agents and monitoring.

Keywords: anticoagulation; extracorporeal life support; monitoring; pediatric.