Development of Consensus Recommendations on the Management of Vitiligo and the Role of Decapeptide in Vitiligo by the Delphi Method

Davinder Parsad; Sanjeev Kandhari; Rachita Dhurat; Bela Shah; Imran Majid; Harikishan Kumar Yadalla; Jagdish Sakhiya; Shital Poojary; P Jagadish; Pravin D Banotkar; Ravindra Babu; Y M Shivakumar; S K Bose; Saleem Jamadar; Monal Shah; Bharat Tank; Ravindra Dhabhai; Sanjay Kumar Mittal; Premanshu Bhushan; Akshi Pandita; Vaibhav Barve

doi:10.4103/ijd.ijd_461_23

Development of Consensus Recommendations on the Management of Vitiligo and the Role of Decapeptide in Vitiligo by the Delphi Method

Indian J Dermatol. 2023 Sep-Oct;68(5):587. doi: 10.4103/ijd.ijd_461_23.

Authors

Davinder Parsad¹, Sanjeev Kandhari², Rachita Dhurat³, Bela Shah⁴, Imran Majid⁵, Harikishan Kumar Yadalla⁶, Jagdish Sakhiya⁷, Shital Poojary⁸, P Jagadish⁹, Pravin D Banotkar¹⁰, Ravindra Babu¹¹, Y M Shivakumar¹², S K Bose¹³, Saleem Jamadar¹⁴, Monal Shah¹⁵, Bharat Tank¹⁶, Ravindra Dhabhai¹⁷, Sanjay Kumar Mittal¹⁸, Premanshu Bhushan¹⁹, Akshi Pandita¹⁹, Vaibhav Barve²⁰

Affiliations

¹ From the Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Kandhari's Skin and Dental Clinic, Srinagar, Jammu and Kashmir, India.
³ Department of Dermatology, LTMMC, Sion Hospital, Srinagar, Jammu and Kashmir, India.
⁴ Department of Dermatology, B. J Medical College and Civil Hospital, Srinagar, Jammu and Kashmir, India.
⁵ Cutis Clinic, Srinagar, Jammu and Kashmir, India.
⁶ Department of Dermatology, Venereology and Leprosy, Rajarajeshwari Medical College, Surat, Gujarat, India.
⁷ Sakhiya Skin Clinic, Surat, Gujarat, India.
⁸ Department of Dermatology, KJ Somaiya Medical College, Bengaluru, Karnataka, India.
⁹ Cuticare Centre, Bengaluru, Karnataka, India.
¹⁰ Saifee Hospital, Bengaluru, Karnataka, India.
¹¹ Raga Clinic, Bengaluru, Karnataka, India.
¹² Inchara Skin Clinic, Mysore, Karnataka, India.
¹³ Indraprastha Apollo, Gadag, Karnataka, India.
¹⁴ Shifa Clinic, Gadag, Karnataka, India.
¹⁵ Haribhakti Skin Clinic, Ahmedabad, Gujarat, India.
¹⁶ Amrut Skin Clinic, Rajkot, Gujarat, India.
¹⁷ Sikar Hospital and Research Centre, Sikar, Rajasthan, India.
¹⁸ Mittal Skin Clinic, Jaipur, Rajasthan, India.
¹⁹ Dr. P N Behl Skin Institute, New Delhi, Delhi, India.
²⁰ KJ Somaiya Medical College, Mumbai, Maharashtra, India.

Abstract

Background: Treatment of vitiligo is still a challenge in dermatology. Literature is sparse on the definitive clinical role of basic fibroblast growth factor (bFGF) in vitiligo patients.

Aims: We decided to generate a consensus in an attempt to answer some critical questions related to the management of vitiligo and the role of bFGF.

Materials and methods: A Delphi method among 21 experts across India was conducted. A consensus (agreement was 75% or greater) was taken on 27 statements on the prevalence, epidemiology, and treatment of vitiligo and the role of bFGF in the management of vitiligo. The consensus process was completed after two rounds.

Results: Topical corticosteroid therapy is the first-line therapy for vitiligo; however, its adverse effects are widely known, especially in sensitive areas. Topical calcineurin inhibitors are preferred in stable vitiligo of the face, neck, genitals, or intertriginous regions as an alternative to topical corticosteroids. Topical bFGF is a relatively newer therapy with a promising role in stable vitiligo. bFGF is safe and effective in inducing repigmentation of vitiligo lesions. Combination therapy of bFGF with other topical therapies, phototherapy, and surgical procedures can be beneficial in patients of vitiligo.

Conclusion: This consensus would complement the currently available literature on bFGF and help the practitioner to recognize the unmet need in the treatment of vitiligo.

Keywords: Delphi method; bFGF; consensus; recommendations; vitiligo.