Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells

Giorgio Giurato; Ilaria Terenzi; Francesco Chiuso; Annamaria Salvati; Francesca Rizzo; Roberta Tarallo; Alessandro Weisz; Giovanni Nassa

doi:10.3389/fcell.2023.1308025

Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells

Front Cell Dev Biol. 2023 Nov 30:11:1308025. doi: 10.3389/fcell.2023.1308025. eCollection 2023.

Authors

Giorgio Giurato^#^{1

2}, Ilaria Terenzi^#¹, Francesco Chiuso³, Annamaria Salvati^{1

4}, Francesca Rizzo^{1

2}, Roberta Tarallo^{1

2}, Alessandro Weisz^{1

2

4}, Giovanni Nassa^{1

2}

Affiliations

¹ Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
² Genome Research Center for Health - CRGS, Baronissi, Italy.
³ Department of Molecular Medicine and Medical Biotechnologies, University Federico II, Naples, Italy.
⁴ Molecular Pathology and Medical Genomics Program, Division of Oncology, AOU 'S. Giovanni di Dio e Ruggi d'Aragona', Università di Salerno, Salerno, Italy.

^# Contributed equally.

No abstract available

Keywords: DOT1l; breast cancer; epigenetics; estrogen receptor alpha; methylation; reduced representation bisulfite sequencing.

Associated data

figshare/10.6084/m9.figshare.22140335.v5

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the AIRC Foundation for Cancer Research (Grant No. IG-23068), the Italian Ministry for University and Research (PRIN 2022: 2022Y79PT4 to AW and PRIN 2022: 202282CMEA to GN), the Italian Ministry of Health (Young Researcher Grant GR-2021-12373937 to GN), and the University of Salerno (Fondi FARB 2022 and 2023). IT is a PhD student of the Research Doctorate in “Molecular Oncology, Immunology, and Experimental Development of Innovative Therapies” of the University of Catanzaro “Magna Graecia.” AS is a resident of the Postgraduate School in Clinical Pathology and Clinical Biochemistry of the University of Salerno.