Selenium-Based Catalytic Scavengers for Concurrent Scavenging of H2 S and Reactive Oxygen Species

Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202317487. doi: 10.1002/anie.202317487. Epub 2024 Jan 2.

Abstract

Hydrogen sulfide (H2 S) is an endogenous gasotransmitter that plays important roles in redox signaling. H2 S overproduction has been linked to a variety of disease states and therefore, H2 S-depleting agents, such as scavengers, are needed to understand the significance of H2 S-based therapy. It is known that elevated H2 S can induce oxidative stress with elevated reactive oxygen species (ROS) formation, such as in H2 S acute intoxication. We explored the possibility of developing catalytic scavengers to simultaneously remove H2 S and ROS. Herein, we studied a series of selenium-based molecules as catalytic H2 S/H2 O2 scavengers. Inspired by the high reactivity of selenoxide compounds towards H2 S, 14 diselenide/monoselenide compounds were tested. Several promising candidates such as S6 were identified. Their activities in buffers, as well as in plasma- and cell lysate-containing solutions were evaluated. We also studied the reaction mechanism of this scavenging process. Finally, the combination of the diselenide catalyst and photosensitizers was used to achieve light-induced H2 S removal. These Se-based scavengers can be useful tools for understanding H2 S/ROS regulations.

Keywords: Diselenides; Hydrogen Peroxide; Hydrogen Sulfide; Oxidative Stress; Scavengers.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Gasotransmitters*
  • Hydrogen Peroxide / pharmacology
  • Hydrogen Sulfide*
  • Oxidative Stress
  • Reactive Oxygen Species
  • Selenium*

Substances

  • Reactive Oxygen Species
  • Selenium
  • Hydrogen Sulfide
  • Gasotransmitters
  • Hydrogen Peroxide