The mechanism of macroautophagy: The movie

Fulvio Reggiori; Patricia Boya; David da Costa; Zvulun Elazar; Eeva-Liisa Eskelinen; Judith Farrés; Sebastian Guettler; Claudine Kraft; Heinz Jungbluth; Ana Martinez; Etienne Morel; Ole Pless; Tassula Proikas-Cezanne; Anne Simonsen

doi:10.1080/27694127.2022.2096115

The mechanism of macroautophagy: The movie

Autophagy Rep. 2022 Sep 14;1(1):414-417. doi: 10.1080/27694127.2022.2096115.

Authors

Fulvio Reggiori^{1

2

3}, Patricia Boya⁴, David da Costa⁵, Zvulun Elazar⁶, Eeva-Liisa Eskelinen⁷, Judith Farrés⁸, Sebastian Guettler⁹, Claudine Kraft^{10

11}, Heinz Jungbluth^{12

13}, Ana Martinez¹⁴, Etienne Morel¹⁵, Ole Pless¹⁶, Tassula Proikas-Cezanne¹⁷, Anne Simonsen¹⁸

Affiliations

¹ Department of Biomedical Sciences of Cells & Systems, University of Groningen, University Medical Centre Groningen, 9713, AV Groningen, The Netherlands.
² Department of Biomedicine, Aarhus University, Ole Worms Allé 4, 8000 Aarhus C, Denmark.
³ Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Høegh-Guldbergs Gade 6B, 8000 Aarhus C, Denmark.
⁴ Centro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
⁵ Adjuvatis, 60 avenue Rockfeller, 69008 Lyon, France.
⁶ Department of Bimolecular Sciences, The Weizmann Institute of Science, 76100, Rehovot, Israel.
⁷ Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
⁸ Anaxomics Biotech S.L., c. Diputació, 237 1-1 08007 Barcelona, Spain.
⁹ Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, United Kingdom.
¹⁰ Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
¹¹ CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
¹² Randall Division of Cell and Molecular Biophysics, Muscle Signalling Section, King's College London, London, United Kingdom.
¹³ Department of Paediatric Neurology, Evelina Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.
¹⁴ Centro de Investigaciones Biomedicas en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
¹⁵ Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, F-75015 Paris, France.
¹⁶ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, ScreeningPort, D-22525 Hamburg, Germany.
¹⁷ Interfaculty Institute of Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, D-72076 Tübingen, Germany.
¹⁸ Department of Molecular Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 1112 Blindern, 0317 Oslo, Norway.

Abstract

This animated movie presents the mechanism of macroautophagy, hereafter autophagy, by showing the molecular features of the formation of autophagosomes, the hallmark organelle of this intracellular catabolic pathway. It is based on our current knowledge and it also illustrates how autophagosomes can recognize and eliminate selected cargoes.

Grants and funding

NWO_OCENW.KLEIN.118/NWO_/Dutch Research Council/Netherlands