Local versus General Anaesthesia for Transcatheter Aortic Valve Implantation (TAVI): A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomised and Propensity-Score Matched Studies

Curr Probl Cardiol. 2024 Mar;49(3):102360. doi: 10.1016/j.cpcardiol.2023.102360. Epub 2023 Dec 19.

Abstract

Transcatheter aortic valve implantation (TAVI) is a common practice for severe aortic stenosis, but the choice between general (GA) and local anesthesia (LA) remains uncertain. We conducted a comprehensive literature review until April 2023, comparing the safety and efficacy of LA versus GA in TAVI procedures. Our findings indicate significant advantages of LA, including lower 30-day mortality rates (RR: 0.69; 95% CI [0.58, 0.82]; p < 0.001), shorter in-hospital stays (mean difference: -0.91 days; 95% CI [-1.63, -0.20]; p = 0.01), reduced bleeding/transfusion incidents (RR: 0.64; 95% CI [0.48, 0.85]; p < 0.01), and fewer respiratory complications (RR: 0.56; 95% CI [0.42, 0.76], p<0.01). Other operative outcomes were comparable. Our findings reinforce prior evidence, presenting a compelling case for LA's safety and efficacy. While patient preferences and clinical nuances must be considered, our study propels the discourse towards a more informed anaesthesia approach for TAVI procedures.

Keywords: Transcatheter aortic valve implantation; general anaesthesia; local anaesthesia; transcatheter aortic valve replacement.

Publication types

  • Systematic Review
  • Meta-Analysis
  • Comparative Study
  • Review

MeSH terms

  • Anesthesia, General*
  • Anesthesia, Local*
  • Aortic Valve Stenosis / surgery
  • Humans
  • Postoperative Complications / mortality
  • Propensity Score*
  • Randomized Controlled Trials as Topic*
  • Transcatheter Aortic Valve Replacement* / adverse effects
  • Transcatheter Aortic Valve Replacement* / methods
  • Treatment Outcome