Metabolism-related signalling pathways involved in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease

Clin Res Hepatol Gastroenterol. 2024 Feb;48(2):102264. doi: 10.1016/j.clinre.2023.102264. Epub 2023 Dec 23.

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) which formerly known as non-alcoholic fatty liver disease (NAFLD) is one of the causes of liver cirrhosis. Currently, a growing number of liver cirrhosis cases develop on the basis of MASLD, and the pathogenesis of MASLD remains unclear. This paper reviews the research progress on the involvement of different metabolism-related signalling pathways in the pathogenesis and development of MASLD.

Keywords: MASLD; Metabolism; NAFLD; Pathogenesis; Signalling pathway.

Publication types

  • Review

MeSH terms

  • Humans
  • Liver Cirrhosis / etiology
  • Metabolic Diseases*
  • Non-alcoholic Fatty Liver Disease* / complications