Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis

Makiko Kido-Nakahara; Daisuke Onozuka; Kenji Izuhara; Hidehisa Saeki; Satoshi Nunomura; Motoi Takenaka; Mai Matsumoto; Yoko Kataoka; Rai Fujimoto; Sakae Kaneko; Eishin Morita; Akio Tanaka; Ryo Saito; Tatsuro Okano; Tomomitsu Miyagaki; Natsuko Aoki; Kimiko Nakajima; Susumu Ichiyama; Kyoko Tonomura; Yukinobu Nakagawa; Risa Tamagawa-Mineoka; Koji Masuda; Takuya Takeichi; Masashi Akiyama; Yozo Ishiuji; Michie Katsuta; Yuki Kinoshita; Chiharu Tateishi; Aya Yamamoto; Akimichi Morita; Haruna Matsuda-Hirose; Yutaka Hatano; Hiroshi Kawasaki; Ayano Fukushima-Nomura; Mamitaro Ohtsuki; Koji Kamiya; Yudai Kabata; Riichiro Abe; Hiroshi Mitsui; Tatsuyoshi Kawamura; Gaku Tsuji; Masutaka Furue; Norito Katoh; Takeshi Nakahara

doi:10.1016/j.alit.2023.12.001

Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis

Allergol Int. 2024 Apr;73(2):332-334. doi: 10.1016/j.alit.2023.12.001. Epub 2023 Dec 27.

Authors

Makiko Kido-Nakahara¹, Daisuke Onozuka², Kenji Izuhara³, Hidehisa Saeki⁴, Satoshi Nunomura³, Motoi Takenaka⁵, Mai Matsumoto⁵, Yoko Kataoka⁶, Rai Fujimoto⁶, Sakae Kaneko⁷, Eishin Morita⁷, Akio Tanaka⁸, Ryo Saito⁸, Tatsuro Okano⁹, Tomomitsu Miyagaki⁹, Natsuko Aoki¹⁰, Kimiko Nakajima¹⁰, Susumu Ichiyama⁴, Kyoko Tonomura¹¹, Yukinobu Nakagawa¹¹, Risa Tamagawa-Mineoka¹², Koji Masuda¹², Takuya Takeichi¹³, Masashi Akiyama¹³, Yozo Ishiuji¹⁴, Michie Katsuta¹⁴, Yuki Kinoshita¹⁵, Chiharu Tateishi¹⁵, Aya Yamamoto¹⁶, Akimichi Morita¹⁶, Haruna Matsuda-Hirose¹⁷, Yutaka Hatano¹⁷, Hiroshi Kawasaki¹⁸, Ayano Fukushima-Nomura¹⁸, Mamitaro Ohtsuki¹⁹, Koji Kamiya¹⁹, Yudai Kabata²⁰, Riichiro Abe²⁰, Hiroshi Mitsui²¹, Tatsuyoshi Kawamura²¹, Gaku Tsuji¹, Masutaka Furue¹, Norito Katoh¹², Takeshi Nakahara²²

Affiliations

¹ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
² Department of Oral Microbe Control, Graduate School of Medicine, Osaka University, Osaka, Japan.
³ Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
⁴ Department of Dermatology, Nippon Medical School, Tokyo, Japan.
⁵ Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
⁶ Department of Dermatology, Osaka Habikino Medical Center, Osaka, Japan.
⁷ Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.
⁸ Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
⁹ Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, Japan.
¹⁰ Department of Dermatology, Kochi Medical School, Kochi, Japan.
¹¹ Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
¹² Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹³ Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
¹⁴ Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
¹⁵ Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
¹⁶ Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
¹⁷ Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan.
¹⁸ Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan.
¹⁹ Department of Dermatology, Jichi Medical University, Tochigi, Japan.
²⁰ Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
²¹ Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
²² Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: [email protected].

PMID: 38151410
DOI: 10.1016/j.alit.2023.12.001

No abstract available

Publication types

Letter

MeSH terms

Antibodies, Monoclonal, Humanized / adverse effects
Biomarkers
Blepharitis* / chemically induced
Blepharitis* / diagnosis
Blepharitis* / drug therapy
Conjunctivitis* / chemically induced
Conjunctivitis* / diagnosis
Humans

Substances

dupilumab
Antibodies, Monoclonal, Humanized
Biomarkers