Clinical pilot study on microfluidic automation of IGH-VJ library preparation for next generation sequencing

Clin Chem Lab Med. 2023 Dec 29;62(7):e164-e167. doi: 10.1515/cclm-2023-1346. Print 2024 Jun 25.

Jacob F Hess^{1

2}, Michaela Kotrová³, Birgit Fricke³, Simona Songia⁴, Silvia Rigamonti⁴, Roberta Cavagna⁵, Manuela Tosi⁵, Nils Paust^{1

2}, Anton W Langerak⁶, Orietta Spinelli⁵, Giovanni Cazzaniga^{4

7}, Monika Brüggemann³, Tobias Hutzenlaub^{1

2}

¹ Hahn-Schickard, Freiburg, Germany.
² Laboratory for MEMS Applications, IMTEK - Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany.
³ Unit for Hematological Diagnostics, II. Medical Department, University Medical Center Schleswig Holstein, Kiel, Germany.
⁴ Centro Tettamanti, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
⁵ Struttura Complessa Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy.
⁶ Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
⁷ School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.

No abstract available

Keywords: automation; high-throughput nucleotide sequencing; microfluidics; precursor cell lymphoblastic leukemia-lymphoma.

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