Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case

Tingting Tao; Jiannong Cen; Chao Xu; Yan Chen; Yanglin Cao; Yanlei Gong; Mingqing Zhu; Suning Chen; Qike Zhang; Li Yao

doi:10.1002/mc.23672

Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case

Mol Carcinog. 2024 Apr;63(4):558-562. doi: 10.1002/mc.23672. Epub 2023 Dec 28.

Authors

Tingting Tao^{1

2}, Jiannong Cen^{1

2}, Chao Xu^{1

2}, Yan Chen^{1

2}, Yanglin Cao^{1

2}, Yanlei Gong^{1

2}, Mingqing Zhu^{1

2}, Suning Chen^{1

2}, Qike Zhang³, Li Yao^{1

2}

Affiliations

¹ Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, People's Republic of China.
² Division of Haematolgy, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
³ Department of Haematology, Gansu Provincial People's Hospital, Lanzhou, People's Republic of China.

PMID: 38153216
DOI: 10.1002/mc.23672

Abstract

Acute promyelocytic leukemia (APL) with typically PML::RARA fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and PML::RARA fusion cannot be detected. In this report, we identified the coexistence of STAT3::RARA and RARA::STAT5b fusions for the first time in a variant APL patient lacking t (15;17)(q22;q21)/PML::RARA fusion. Then, this patient was resistant to all-trans retinoic acid combined arsenic trioxide chemotherapy. Accurate detection of RARA gene partners is crucial for variant APL, and effective therapeutic regime is urgently needed.

Keywords: RARA::STAT5b; STAT3::RARA; acute promyelocytic leukemia; variant acute promyelocytic leukemia.

MeSH terms

Humans
Leukemia, Promyelocytic, Acute* / drug therapy
Leukemia, Promyelocytic, Acute* / genetics
STAT3 Transcription Factor / genetics
Tretinoin

Substances

Tretinoin
STAT3 protein, human
STAT3 Transcription Factor

Abstract

MeSH terms

Substances

Grants and funding