Ambulatory amoxicillin use for common acute respiratory infections during a national shortage: Results from the SHARPS-OP benchmarking collaborative

Nicole M Poole; Brian R Lee; Matthew P Kronman; Michael J Smith; Sameer J Patel; Rosemary Olivero; Bethany A Wattles; Joshua Herigon; Ann Wirtz; Rana E El Feghaly

doi:10.1016/j.ajic.2023.12.014

Ambulatory amoxicillin use for common acute respiratory infections during a national shortage: Results from the SHARPS-OP benchmarking collaborative

Am J Infect Control. 2024 May;52(5):614-617. doi: 10.1016/j.ajic.2023.12.014. Epub 2023 Dec 27.

Authors

Affiliations

¹ Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
² Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO; Department of Pediatrics, University of Missouri Kansas City, Kansas City, MO.
³ Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA.
⁴ Duke University Department of Pediatrics and Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, NC.
⁵ Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago IL.
⁶ Department of Pediatric and Human Development, Michigan State College of Human Medicine; Helen DeVos Children's Hospital, Grand Rapids, MI.
⁷ Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY.
⁸ Department of Pharmacy, Children's Mercy Kansas City, Kansas City, MO; Department of Pharmacy, University of Missouri Kansas City, Kansas City, MO.
⁹ Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO; Department of Pediatrics, University of Missouri Kansas City, Kansas City, MO. Electronic address: [email protected].

PMID: 38158158
DOI: 10.1016/j.ajic.2023.12.014

Abstract

We quantified antibiotic prescribing for ambulatory pediatric acute respiratory illness at 22 institutions in "pre-shortage" (Jan 2019-Sep 2022) and "shortage" (Oct 2022-Mar 2023) periods for amoxicillin. While acute respiratory illness prescribing increased across settings, the proportion of amoxicillin prescriptions decreased. Variation was seen within and between institutions.

Keywords: Amoxicillin shortage; Antimicrobial stewardship; Emergency department; Outpatient; Primary care clinic; Urgent care clinic.