Host factor KAP1 coordinates temporal control between transcription and replication

Sarah Preston-Alp; Italo Tempera

doi:10.1016/j.tim.2023.12.003

Host factor KAP1 coordinates temporal control between transcription and replication

Trends Microbiol. 2024 Feb;32(2):122-123. doi: 10.1016/j.tim.2023.12.003. Epub 2023 Dec 29.

Authors

Sarah Preston-Alp¹, Italo Tempera²

Affiliations

¹ The Wistar Institute, Philadelphia, PA, USA.
² The Wistar Institute, Philadelphia, PA, USA. Electronic address: [email protected].

PMID: 38160193
PMCID: PMC11262421 (available on 2025-02-01)
DOI: 10.1016/j.tim.2023.12.003

Abstract

Temporal control of transcription and replication is necessary for efficient Epstein-Barr virus reactivation. Xu et al. identified the KAP1/EA-D/ATM axis as a critical regulator of these processes. This discovery illuminates the collaboration between host and viral factors as an essential interaction for viral reactivation.

MeSH terms

Epstein-Barr Virus Infections*
Herpesvirus 4, Human / genetics
Humans
Virus Replication / genetics

Grants and funding

T32 CA009171/CA/NCI NIH HHS/United States