Mutagenicity of aminophenyl and nitrophenyl ethers, sulfides, and disulfides

Mutat Res. 1979 Jun;67(2):123-31. doi: 10.1016/0165-1218(79)90123-x.

Abstract

The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4'-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4'-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, --S-- greater than --O-- greater than --CH2--CH2-- greater than or equal to --S--S--. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-AMINOPHENYl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester straains TA100 and TA98.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aniline Compounds / pharmacology*
  • Benzhydryl Compounds / pharmacology
  • Drug Evaluation, Preclinical
  • Genetic Techniques
  • Mutagens*
  • Salmonella typhimurium / genetics

Substances

  • Aniline Compounds
  • Benzhydryl Compounds
  • Mutagens
  • 4,4'-diaminodiphenylmethane