Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity

Manuela Lizarralde-Guerrero; Laura Zucaro; Guido Kroemer; Jonathan G Pol

doi:10.1080/2162402X.2023.2300520

Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity

Oncoimmunology. 2024 Jan 4;13(1):2300520. doi: 10.1080/2162402X.2023.2300520. eCollection 2024.

Authors

Manuela Lizarralde-Guerrero^{1

2

3}, Laura Zucaro^{1

2

4}, Guido Kroemer^{1

2

5}, Jonathan G Pol^{1

2}

Affiliations

¹ Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
² Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
³ Université Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, France.
⁴ Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.
⁵ Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Abstract

Advances in single-cell RNA and T cell receptor (TCR) sequencing allow to study the specificity and functionality of tumor-infiltrating T lymphocytes. A recent study unravels fundamental differences between microsatellite-instable (MSI) colorectal cancers, in which T cells tend to be tumor-specific, and microsatellite-stable (MSS) cancers, in which T cells exhibit bystander features.

Keywords: Colorectal cancer; T cell receptor; microsatellite instability; single-cell transcriptomics; tumor-infiltrating lymphocytes.

Publication types

Editorial

MeSH terms

Colorectal Neoplasms* / genetics
Humans
Lymphocytes, Tumor-Infiltrating
Microsatellite Instability
Single-Cell Analysis
T-Lymphocytes*

Grants and funding

This work was supported by the no funding.