Unanswered questions following reports of secondary malignancies after CAR-T cell therapy

Affiliations

• ¹ Center for Cellular Immunotherapies and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA. [email protected].
• ² Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
• ³ Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
• ⁴ Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
• ⁵ Cell Therapy and Transplant, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic in Arizona, Phoenix, AZ, USA.
• ⁷ Transplantation and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ⁸ Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
• ⁹ Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁰ Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
• ¹¹ Cellular Immunotherapy Program, Mass General Cancer Center and Harvard Medical School, Cambridge, MA, USA.
• ¹² Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, USA.
• ¹³ University Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute Milano, Milan, Italy.
• ¹⁴ Hematology and BMT unit, IRCCS San Raffaele scientific institute, Milano, Italy.
• ¹⁵ Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
• ¹⁶ Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK.
• ¹⁷ Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
• ¹⁸ Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA.
• ¹⁹ Center for Cancer Cell Therapy, Stanford Cancer Institute and Departments of Pediatrics and Medicine, Stanford University, Palo Alto, CA, USA.
• ²⁰ Parker Institute for Cancer Immunotherapy, Palo Alto, CA, USA.
• ²¹ Center for Cellular Immunotherapies and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
• ²² Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.
• ²³ Clinical Hematology Department, Institut Català d'Oncologia - L'Hospitalet, IDIBELL, University of Barcelona, Barcelona, Spain.
• ²⁴ Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ²⁵ Department of Medicine, Weill Cornell Medical College, New York, NY, USA.