Plumeriapropionics A-E, Carboxyl-Substituted Phenylpropionic Acid Derivatives with Anti-Inflammatory Activity from Plumeria rubra L

Xueming Zhou; Minlin Gan; Meizhu Wu; Ting Zheng; Chuluunbaatar Enkhchimeg; Haixiang Li; Shuo Feng; Jingqi Zhou; Xinming Song

doi:10.3390/molecules29010115

Plumeriapropionics A-E, Carboxyl-Substituted Phenylpropionic Acid Derivatives with Anti-Inflammatory Activity from Plumeria rubra L

Molecules. 2023 Dec 24;29(1):115. doi: 10.3390/molecules29010115.

Authors

Xueming Zhou^{1

2}, Minlin Gan^{1

2}, Meizhu Wu^{1

2}, Ting Zheng^{1

2}, Chuluunbaatar Enkhchimeg^{1

2}, Haixiang Li^{1

2}, Shuo Feng^{1

2}, Jingqi Zhou^{1

2}, Xinming Song^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University, Haikou 571158, China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Abstract

Five rare carboxyl-substituted phenylpropionic acid derivatives, plumeriapropionics A-E (1-5), together with one known analog, cerberic acid B (6), were isolated from flowers of Plumeria rubra L. Their structures were elucidated using comprehensive spectroscopic methods. To date, only one compound of this structural type has been reported. The inhibitory activities of compounds 1-6 against nitric oxide (NO) production induced by lipopolysaccharide (LPS) were evaluated in vitro using mouse macrophage RAW264.7 cells. Compounds 1-6 showed remarkable inhibitory activities on NO production, with IC₅₀ values in the range of 6.52 ± 0.23 to 35.68 ± 0.17 µM. These results indicate that the discovery of carboxyl-substituted phenylpropionic acid derivatives from the flowers of P. rubra, which show significant anti-inflammatory properties, could be of great importance for the research and development of novel natural anti-inflammatory agents.

Keywords: Plumeria rubra; anti-inflammatory activity; carboxyl-substituted phenylpropionic acid; plumeriapropionics.

MeSH terms

Animals
Anti-Inflammatory Agents* / pharmacology
Apocynaceae*
Flowers
Lipopolysaccharides / pharmacology
Mice
Nitric Oxide
Organic Chemicals

Substances

Anti-Inflammatory Agents
Lipopolysaccharides
Nitric Oxide
Organic Chemicals

Grants and funding

This work was supported by the National Natural Science Foundation of China (82260831) and the Innovative research project of Hainan college students (S202211658036, RC2100006644).