The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas

Endocrine. 2024 May;84(2):694-703. doi: 10.1007/s12020-023-03681-4. Epub 2024 Jan 11.

Abstract

Purpose: Preoperative medical management is critical to prevent intraoperative cardiovascular complications in patients with pheochromocytomas and paragangliomas (PPGLs). Initial treatment involves α-adrenergic receptor blockers. However, while the routine use of metyrosine alongside these blockers is not strongly recommended due to a lack of evidence supporting its efficacy and associated safety concerns, there are previous studies on combination therapy with phenoxybenzamine and metyrosine. There are few reports on combination therapy with the selective α1-adrenergic receptor blocker doxazosin. Therefore, we investigated this combination treatment, which theoretically can affect perioperative outcomes in patients with PPGLs. To our knowledge, this is the first such study.

Methods: This retrospective single-center observational study involved 51 patients who underwent surgical resection of PPGLs at Kobe University Hospital between 2014 and 2022. All patients received doxazosin at maximum doses. Fourteen patients received concomitant metyrosine, while 37 received doxazosin alone. Their perioperative outcomes were compared.

Results: No severe event, such as acute coronary syndrome, was observed in either group. Intraoperatively, the doxazosin + metyrosine group exhibited a lower median minimum systolic blood pressure (56 [54-60] vs. 68 [59-74] mmHg, P = 0.03) and required lower median remifentanil (P = 0.04) and diltiazem (P = 0.02) doses than the doxazosin-alone group.

Conclusion: The combination of metyrosine and doxazosin as a preoperative treatment for PPGLs affects intraoperative circulatory hemodynamics, such as a reduced occurrence of blood pressure elevation during surgery. Further research is necessary to identify patients who will benefit most from this combination treatment.

Keywords: Doxazosin; Metyrosine; Paraganglioma; Pheochromocytoma; α-Adrenergic receptor blocker.

Publication types

  • Observational Study

MeSH terms

  • Adrenal Gland Neoplasms* / drug therapy
  • Adrenal Gland Neoplasms* / surgery
  • Adrenergic alpha-1 Receptor Antagonists* / administration & dosage
  • Adrenergic alpha-1 Receptor Antagonists* / therapeutic use
  • Adult
  • Aged
  • Doxazosin* / administration & dosage
  • Doxazosin* / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Paraganglioma* / drug therapy
  • Paraganglioma* / surgery
  • Pheochromocytoma* / drug therapy
  • Pheochromocytoma* / surgery
  • Preoperative Care / methods
  • Retrospective Studies
  • Treatment Outcome
  • alpha-Methyltyrosine* / administration & dosage
  • alpha-Methyltyrosine* / pharmacology
  • alpha-Methyltyrosine* / therapeutic use

Substances

  • Doxazosin
  • alpha-Methyltyrosine
  • Adrenergic alpha-1 Receptor Antagonists