The potential role of miRNAs in the pathogenesis of schizophrenia - A focus on signaling pathways interplay

Pathol Res Pract. 2024 Feb:254:155102. doi: 10.1016/j.prp.2024.155102. Epub 2024 Jan 9.

Abstract

microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.

Keywords: Biomarker; Diagnosis; Dopamine system; GABA system; MiRNA; Schizophrenia.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Brain / metabolism
  • Humans
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Schizophrenia* / genetics
  • Schizophrenia* / metabolism
  • Signal Transduction

Substances

  • MicroRNAs
  • Biomarkers