Combinatorial Approaches for Chemotherapies and Targeted Therapies With Radiation: United Efforts to Innovate in Patient Care

Salma K Jabbour; Ritesh Kumar; Bethany Anderson; Junzo P Chino; Krishan R Jethwa; Lachlan McDowell; Andrea C Lo; Dawn Owen; Erqi L Pollom; Alison C Tree; Derek S Tsang; Sue S Yom

doi:10.1016/j.ijrobp.2024.01.010

Combinatorial Approaches for Chemotherapies and Targeted Therapies With Radiation: United Efforts to Innovate in Patient Care

Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1240-1261. doi: 10.1016/j.ijrobp.2024.01.010. Epub 2024 Jan 10.

Authors

Salma K Jabbour¹, Ritesh Kumar², Bethany Anderson³, Junzo P Chino⁴, Krishan R Jethwa⁵, Lachlan McDowell⁶, Andrea C Lo⁷, Dawn Owen⁵, Erqi L Pollom⁸, Alison C Tree⁹, Derek S Tsang¹⁰, Sue S Yom¹¹

Affiliations

¹ Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Jersey. Electronic address: [email protected].
² Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Jersey.
³ Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
⁴ Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina.
⁵ Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
⁶ Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia.
⁷ Department of Radiation Oncology, BC Cancer Vancouver Centre, Vancouver, British Columbia, Canada.
⁸ Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California.
⁹ Royal Marsden NHS Foundation Trust, London, United Kingdom.
¹⁰ Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
¹¹ Department of Radiation Oncology, University of California San Francisco, California.

PMID: 38216094
DOI: 10.1016/j.ijrobp.2024.01.010

Abstract

Combinatorial therapies consisting of radiation therapy (RT) with systemic therapies, particularly chemotherapy and targeted therapies, have moved the needle to augment disease control across nearly all disease sites for locally advanced disease. Evaluating these important combinations to incorporate more potent therapies with RT will aid our understanding of toxicity and efficacy for patients. This article discusses multiple disease sites and includes a compilation of contributions from expert Red Journal editors from each disease site. Leveraging improved systemic control with novel agents, we must continue efforts to study novel treatment combinations with RT.

Publication types

Review

MeSH terms

Combined Modality Therapy
Humans
Patient Care*