Trans-regulatory variant network contributes to missing heritability

Vanessa Pereira; Elena Kuzmin

doi:10.1016/j.xgen.2023.100470

Trans-regulatory variant network contributes to missing heritability

Cell Genom. 2024 Jan 10;4(1):100470. doi: 10.1016/j.xgen.2023.100470.

Authors

Vanessa Pereira¹, Elena Kuzmin²

Affiliations

¹ Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada.
² Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Canada. Electronic address: [email protected].

Abstract

In a recent Cell Genomics article, Tsouris et al.¹ analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira and Elena Kuzmin discuss the authors' findings and the wider context in missing heritability research in this preview.

MeSH terms

Saccharomyces cerevisiae* / genetics
Transcriptome*