LEF-1 immunohistochemistry, a better diagnostic biomarker than β-catenin for medulloblastoma, WNT-activated subtyping

Affiliations

• ¹ Department of Neuropathology, GHU Paris-Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.
• ² Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
• ³ Université de Paris, Paris, France.
• ⁴ Institute of Psychiatry and Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, Paris, France.
• ⁵ Institut Curie, Paris Sciences Lettres University, SIREDO, INSERM U830, Laboratory of translational research in pediatric oncology, Paris, France.
• ⁶ INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
• ⁷ Department of Biochemistry and Oncogenetics, Paul Brousse Hospital, Villejuif, France.
• ⁸ Institut Curie, Laboratory of Somatic Genetics, PMDT, Paris Sciences Lettres Research University Paris, France.
• ⁹ Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
• ¹⁰ Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, France.
• ¹¹ Department of Children and Adolescents Oncology, Gustave Roussy, Paris Saclay University, Villejuif, France.