In the nationwide study of epikeratophakia, 116 ophthalmic surgeons performed 352 procedures for the correction of myopia; 256 of the eyes had 30 or more days of follow-up after suture removal. Of 204 eyes, 153 (75%) were within 30% of emmetropia after surgery. Of 208 eyes, 202 (97%) had postoperative best corrected visual acuity within two Snellen lines or better of their preoperative visual acuity. All but one patient improved uncorrected visual acuity. Of the 120 patients who equaled or improved their preoperative best corrected visual acuity, 116 (97%) were within two Snellen lines of their preoperative measurement between 30 and 60 days after suture removal. Corneal astigmatism changed from a preoperative mean (+/- S.D.) of 1.4 +/- 0.8 diopters to a postoperative mean of 2.6 +/- 2.1 diopters. Of 352 tissue lenses, 36 (10%) were removed, largely as a result of inaccurate power, decay, or failure to reepithelialize, and 17 of these eyes underwent a second successful epikeratophakia procedure.